The Model Book

A curated catalogue of AI models for biology. See each record for sources and review dates.

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Task

License

Grade

Model	Org	Task	Params	Top Benchmark	Score	License	Cost	Grade ↑	Updated
AlphaFold3	Google DeepMind	Structure Prediction	~600M	CASP15	0.85 GDT-TS (avg)	restricted	Free via AlphaFold Server (rate-limited), enterprise pricing undisclosed	A	Updated 6 months ago
Boltz-2	MIT	Structure Prediction	~400M	POSEBUSTERS	72% valid	open	Self-hosted — ~$0.03/prediction on cloud GPU	A-	Updated 7 months ago
Boltz-1	MIT	Structure Prediction	~300M	CASP15	0.82 GDT-TS (avg)	open	Self-hosted only — ~$0.02/prediction on cloud GPU	A-	Updated 7 months ago
Chai-1	Chai Discovery	Structure Prediction	~500M	CASP15	0.83 GDT-TS (avg)	non-commercial	Free via Chai Discovery platform (rate-limited), self-hosted for research	B+	Updated 7 months ago
RoseTTAFold All-Atom	UW Baker Lab	Structure Prediction	~100M	CASP15	0.79 GDT-TS (avg)	open	Self-hosted — ~$0.02/prediction on cloud GPU	B+	Updated 8 months ago
OmegaFold	HeliXon	Structure Prediction	~100M	CAMEO	0.72 lDDT (avg)	non-commercial	Self-hosted — fast inference, low compute cost	B	Updated 9 months ago

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