The Model Book

A curated catalogue of AI models for biology. See each record for sources and review dates.

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Task

License

Grade

Model	Org	Task	Params	Top Benchmark	Score	License	Cost	Grade ↑	Updated
AlphaFold3	Google DeepMind	Structure Prediction	~600M	CASP15	0.85 GDT-TS (avg)	restricted	Free via AlphaFold Server (rate-limited), enterprise pricing undisclosed	A	Updated 6 months ago
ProteinMPNN	UW Baker Lab	Sequence Design	~2M	PROTEINGYM	52% recovery rate	open	Negligible — runs on laptop hardware	A	Updated 8 months ago
Boltz-2	MIT	Structure Prediction	~400M	POSEBUSTERS	72% valid	open	Self-hosted — ~$0.03/prediction on cloud GPU	A-	Updated 7 months ago
Boltz-1	MIT	Structure Prediction	~300M	CASP15	0.82 GDT-TS (avg)	open	Self-hosted only — ~$0.02/prediction on cloud GPU	A-	Updated 7 months ago
RFdiffusion	UW Baker Lab	Protein Design	~300M	PROTEINGYM	N/A (generative)	open	Self-hosted — ~$0.01/design on cloud GPU	A-	Updated 8 months ago
AlphaFold-Multimer	Google DeepMind	Complex Prediction	~400M	DOCKQ	0.65 DockQ	restricted	Self-hosted — moderate GPU cost, slower than single-chain AF2	A-	Updated 8 months ago
ESM-3	EvolutionaryScale (Meta origin)	Protein Language Model	~98B	PROTEINGYM	0.47 Spearman (avg)	open	Self-hosted or via EvolutionaryScale API (pricing varies)	B+	Updated 7 months ago
Chai-1	Chai Discovery	Structure Prediction	~500M	CASP15	0.83 GDT-TS (avg)	non-commercial	Free via Chai Discovery platform (rate-limited), self-hosted for research	B+	Updated 7 months ago
Evo-2	Arc Institute	DNA Language Model	~7B	PROTEINGYM	N/A	open	Self-hosted — moderate GPU requirements	B+	Updated 7 months ago
RoseTTAFold All-Atom	UW Baker Lab	Structure Prediction	~100M	CASP15	0.79 GDT-TS (avg)	open	Self-hosted — ~$0.02/prediction on cloud GPU	B+	Updated 8 months ago
OmegaFold	HeliXon	Structure Prediction	~100M	CAMEO	0.72 lDDT (avg)	non-commercial	Self-hosted — fast inference, low compute cost	B	Updated 9 months ago
DiffDock	MIT	Molecular Docking	~50M	POSEBUSTERS	58% valid	open	Self-hosted — ~$0.005/docking on cloud GPU	B	Updated 9 months ago

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